Accompanied by his mischievous monkey and the mysterious Agent 355, Yorick embarks on a transcontinental journey to find his girlfriend and discover why he is the last man on Earth. This volume finds Yorick, Agent 355 and Dr. Mann traveling across the Pacific to Japan in pursuit of Yorick's stolen monkey Ampersand, whose innards may hold the key to mankind's future. Collects issues #32-36 of the runaway hit Vertigo series by Brian K. Vaughan (EX-MACHINA, ASTONISHING X-MEN, RUNAWAYS) and Pia Guerra.