With Galactus defeated and Dr. Doom moping behind bars, Super Hero City is finally safe - that is, until Thanos goes in search of the powerful Infinity Gauntlet! Although they are without their comrade-in-laughter, Silver Surfer, the Super Hero Squad - Iron Man, Thor, Hulk, Wolverine, and Falcon - must once again come together to take on any evil that threatens the peace and safety of the Marvel universe.