Renowned scientist Victor Helios (Thomas Kretschmann) and his prototype creation, Deucalion (Vincent Perez), have manages to exist nearly 200 years through genetic manipulation. Now operating out of New Orleans, Helios has established a genome research institute that secretly produces a "perfect" race of people designed to replace mankind. But tortured by their own existence, the mad doctor's creations are becoming increasingly unpredictable and dangerous. Parker Posey, Adam Goldberg, Ivana Milicevic, and Micahel Madsen also star. Executive Producer of the film is MArtin Scorsese.