Nathan Andrews has grown up and is now a medical resident. when the young doctor loses a patient, he begins to rethink his career and moves back home with his father. Just as Nathan is settling in, his world begins to crumble when the lives of the woman he loves and an innocent young boy are in crisis. Nathan finds himself questioning God, fate, and the fragility of life, all the while hoping for a Christmas miracle. Rob Lowe, Neil Patrick Harris, Rebecca Gayheart, and Angus T. Jones star.